Prior H1N1 Influenza Infection and Susceptibility of Cleveland Family Study Participants during the H2N2 Pandemic of 1957: An Experiment of Nature
Identifieur interne : 000121 ( 1957/Analysis ); précédent : 000120; suivant : 000122Prior H1N1 Influenza Infection and Susceptibility of Cleveland Family Study Participants during the H2N2 Pandemic of 1957: An Experiment of Nature
Auteurs : Suzanne L. Epstein [États-Unis]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2006.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Dossiers médicaux, Enfant, Enfant d'âge préscolaire, Flambées de maladies, Grippe humaine (immunologie), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Nourrisson, Nouveau-né, Ohio (épidémiologie), Réactions croisées, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (pathogénicité), Surveillance de la population.
- MESH :
- immunologie : Grippe humaine, Sous-type H1N1 du virus de la grippe A.
- pathogénicité : Sous-type H2N2 du virus de la grippe A.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine, Ohio.
- Adolescent, Adulte, Adulte d'âge moyen, Dossiers médicaux, Enfant, Enfant d'âge préscolaire, Flambées de maladies, Humains, Nourrisson, Nouveau-né, Réactions croisées, Surveillance de la population.
English descriptors
- KwdEn :
- Adolescent, Adult, Child, Child, Preschool, Cross Reactions, Disease Outbreaks, Humans, Infant, Infant, Newborn, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H2N2 Subtype (pathogenicity), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (virology), Medical Records, Middle Aged, Ohio (epidemiology), Population Surveillance.
- MESH :
- geographic , epidemiology : Ohio.
- epidemiology : Influenza, Human.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza, Human.
- pathogenicity : Influenza A Virus, H2N2 Subtype.
- virology : Influenza, Human.
- Adolescent, Adult, Child, Child, Preschool, Cross Reactions, Disease Outbreaks, Humans, Infant, Infant, Newborn, Medical Records, Middle Aged, Population Surveillance.
Abstract
During a pandemic, influenza vaccines that rely on neutralizing antibodies to protect against matched viruses might not be available early enough. Much broader (heterosubtypic) immune protection is seen in animals. Do humans also have cross-subtype immunity? To investigate this issue, archival records from the Cleveland Family Study, which was conducted before and during the 1957 pandemic (during which a shift from subtype H1N1 to H2N2 occurred), were analyzed. Only 5.6% of the adults who had had symptomatic influenza A in earlier study years developed influenza during the pandemic, despite living in households with participants who had influenza. In contrast, 55.2% of the children who had had symptomatic influenza A contracted it again. These findings suggest an impact of accumulated heterosubtypic immunity during a pandemic. Such immunity, as well as its implications for vaccination, should be further investigated
Url:
DOI: 10.1086/498980
Affiliations:
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ISTEX:096BCA41B9788CF5AEE2095B186BB9C56D0DBD14Le document en format XML
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